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Rheumatology 2000; 39: 445
© 2000 British Society for Rheumatology

Letters to the Editor

Susceptibility to ankylosing spondylitis

N. CARTER, L. WILLIAMSON, L. G. KENNEDY1, M. A. BROWN and B. P. WORDSWORTH

Wellcome Trust Centre for Human Genetics, Headington, Oxford OX3 7BN and
1 Royal National Hospital for Rheumatic Diseases, Upper Borough Walls, Bath BA1 1RL, UK

SIR The association between HLA-B27 (B27) and ankylosing spondylitis (AS) has been known for 25 yr. Familial aggregation in AS is well established, and first-degree relatives of AS patients have been shown to be at increased risk of developing the disease. The recurrence risk in siblings of AS patients is quite uncertain, previous studies have variously reported recurrence risks between 6.9 and 27% [. . . [Full Text of this Article]

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