Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Wedderburn, L. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wedderburn, L. R.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Rheumatology 2000; 39: 458-462
© 2000 British Society for Rheumatology

Editorials

Tracking T cells in arthritis

L. R. Wedderburn

Departments of Rheumatology and Molecular Pathology, University College London, Windeyer Institute of Medical Sciences, 46 Cleveland Street, London W1P 6DB, UK

The first 150 words of the full text of this article appear below.

In the 25 yr since the demonstration that specific recognition of antigens by T lymphocytes requires interaction with a self major histocompatibility complex (MHC) molecule [1], significant advances have been made in our understanding of this process. Initial observations of MHC associations with autoimmune disease involved the class I allele HLA-B27 with spondyloarthropathies in both adults and children [2, 3]. Subsequently, part of the inherited susceptibility to other arthritides was mapped to the MHC, in particular the association of severe rheumatoid arthritis (RA) with class II genes coding for HLA-DRß molecules [4, 5], which share a common sequence in positions 67–74 [6]. Strong associations with MHC DRB1 alleles have also been recognized in the chronic arthritides of children, now collectively known as juvenile idiopathic arthritis (JIA). These differ from the RA-associated alleles and map to specific subgroups of disease, such . . . [Full Text of this Article]


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?