Rheumatology 2000; 39: 804-805
© 2000 British Society for Rheumatology
Letters to the Editor |
Plasma adrenomedullin level in systemic lupus erythematosus
Department of Medicine, The University of Hong Kong, Hong Kong, SAR, China
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SIR, Human adrenomedullin (AM) is a 52-amino acid peptide hormone first isolated from phaeochromocytoma and the adrenal medulla [1]. AM-like immunoreactivity is also found in the heart, lungs and kidneys, as well as in plasma. The physiological role of AM is not well understood, but the plasma AM level is elevated in a number of disease states, including essential hypertension, coronary artery disease, congestive heart failure and renal failure [2]. AM is a vasodilator, through its direct action on vascular smooth muscle to increase intracellular cAMP and the stimulation of endothelial
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A. Mak, B. M. Y. Cheung, C. C. Mok, R. Leung, and C. S. Lau Adrenomedullin--a potential disease activity marker and suppressor of nephritis activity in systemic lupus erythematosus Rheumatology, October 1, 2006; 45(10): 1266 - 1272. [Abstract] [Full Text] [PDF] |
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