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Rheumatology 2000; 39: 804-805
© 2000 British Society for Rheumatology


Letters to the Editor

Plasma adrenomedullin level in systemic lupus erythematosus

B. M. Y. Cheung, C.-S. Lau, R. Y. H. Leung, K. K. Tong and C. R. Kumana

Department of Medicine, The University of Hong Kong, Hong Kong, SAR, China

The first 10% of the full text of this article appears below.

SIR, Human adrenomedullin (AM) is a 52-amino acid peptide hormone first isolated from phaeochromocytoma and the adrenal medulla [1]. AM-like immunoreactivity is also found in the heart, lungs and kidneys, as well as in plasma. The physiological role of AM is not well understood, but the plasma AM level is elevated in a number of disease states, including essential hypertension, coronary artery disease, congestive heart failure and renal failure [2]. AM is a vasodilator, through its direct action on vascular smooth muscle to increase intracellular cAMP and the stimulation of endothelial . . . [Full Text of this Article]


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A. Mak, B. M. Y. Cheung, C. C. Mok, R. Leung, and C. S. Lau
Adrenomedullin--a potential disease activity marker and suppressor of nephritis activity in systemic lupus erythematosus
Rheumatology, October 1, 2006; 45(10): 1266 - 1272.
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