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Rheumatology 2001; 40: 1293-1298
© 2001 British Society for Rheumatology

Paediatric Rheumatology

Central nervous system complications in two cases of juvenile onset dermatomyositis

Paediatric Rheumatology/Series Editor: P. Woo

A. V. Ramanan, S. Sawhney and K. J. Murray

Juvenile Dermatomyositis Research Centre, Rheumatology Unit, Great Ormond Street Hospital and the Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK

Abstract

Central nervous system (CNS) complications are rarely reported in either juvenile or adult onset inflammatory myositides, such as dermatomyositis and polymyositis. We report two children, aged 4 and 10 yr respectively, with a diagnosis of juvenile dermatomyositis, both of whom subsequently developed clinical features of severe CNS involvement, possibly consistent with cerebral vasculopathy. One child died from apparent brainstem involvement; the other developed seizures, pseudoseizures and clinical depression which responded to aggressive immunosuppression. Although the vasculopathy or vasculitis underlying this disorder is known to have a systemic distribution, CNS involvement has rarely been reported and may be under-recognized.

KEY WORDS: Dermatomyositis, Cerebral vasculopathy, Seizure, Central nervous system.

Notes

Correspondence to: K. J. Murray.


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