Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (35)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Fujii, T.
Right arrow Articles by Mimori, T.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Fujii, T.
Right arrow Articles by Mimori, T.
Related Collections
Right arrow Immunogenetics
Right arrow Systemic Lupus Erythematosus and Autoimmunity
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Rheumatology 2001; 40: 1398-1404
© 2001 British Society for Rheumatology

Original Papers

Cytokine and immunogenetic profiles in Japanese patients with adult Still's disease. Association with chronic articular disease

T. Fujii, T. Nojima, H. Yasuoka, S. Satoh, K. Nakamura, M. Kuwana, A. Suwa, M. Hirakata and T. Mimori

Section of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan

Objective. To determine cytokines and MHC class II alleles in Japanese patients with adult Still's disease (ASD) and clarify the association between those profiles and chronic articular disease.

Methods. Of 35 patients with ASD (13 men, 22 women, mean age at onset 34.0 yr), 17 (49%) had chronic arthritis (>6 months, chronic articular ASD) and 18 (51%) lacked chronic arthritis (systemic ASD). Cytokines and cytokine receptors in sera were measured by ELISA. Correlations of each cytokine with disease activity or C-reactive protein (CRP) were determined. MHC class II alleles were examined by polymerase chain reaction methods.

Results. In chronic articular ASD, female gender was more frequent and liver dysfunction and myalgia were rarer than in systemic ASD. In active disease, the white blood cell count was lower, but total IgG was greater in patients with chronic articular ASD than in those with systemic ASD. Tumour necrosis factor (TNF) {alpha}, soluble TNF receptor 2 and interleukin (IL)-18 were increased in both types of ASD, even in remission. Soluble IL-2 receptors, IL-4 and IL-18 levels were correlated with disease activity or CRP value only in chronic articular ASD. Interferon {gamma} and IL-8 remained increased only in chronic articular ASD, even when disease activity, including IL-6 and CRP, was low. DRB1*1501 (DR2) and DRB1*1201 (DR5) alleles were more frequent in chronic articular than in systemic ASD, whereas DQB1*0602 (DQ1) was frequently observed in both types of ASD.

Conclusion. The present study suggests that ASD with chronic articular disease has distinct clinical, cytokine and immunogenetic profiles.

KEY WORDS: Adult Still's disease, Cytokines, MHC class II alleles, Chronic arthritis.

Correspondence to: T. Fujii, Department of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 The Journal of RheumatologyHome page
D.-Y. CHEN, Y.-M. CHEN, H.-H. CHEN, C.-W. HSIEH, C.-C. LIN, and J.-L. LAN
Functional Association of Interleukin 18 Gene -607 (C/A) Promoter Polymorphisms with Disease Course in Chinese Patients with Adult-onset Still's Disease
J Rheumatol, October 1, 2009; 36(10): 2284 - 2289.
[Abstract] [Full Text] [PDF]

Home page
 The Journal of RheumatologyHome page
H.-T. LEE, W.-S. CHEN, K.-H. SUN, C.-T. CHOU, and C.-Y. TSAI
Increased Spontaneous But Decreased Mitogen-stimulated Expression and Excretion of Interleukin 18 by Mononuclear Cells in Patients with Active Systemic Lupus Erythematosus
J Rheumatol, September 1, 2009; 36(9): 1910 - 1916.
[Abstract] [Full Text] [PDF]

Home page
 Ann Rheum DisHome page
P. Woo
Anakinra treatment for systemic juvenile idiopathic arthritis and adult onset Still disease
Ann Rheum Dis, March 1, 2008; 67(3): 281 - 282.
[Full Text] [PDF]

Home page
 Ann Rheum DisHome page
T Lequerre, P Quartier, D Rosellini, F Alaoui, M De Bandt, O Mejjad, I Kone-Paut, M Michel, E Dernis, M Khellaf, et al.
Interleukin-1 receptor antagonist (anakinra) treatment in patients with systemic-onset juvenile idiopathic arthritis or adult onset Still disease: preliminary experience in France
Ann Rheum Dis, March 1, 2008; 67(3): 302 - 308.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.