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Rheumatology 2001; 40: 227-228
© 2001 British Society for Rheumatology

Letters to the Editor

Familial erosive arthritis associated with seroreactivity to human intracisternal retroviral particle type I (HIAP-I)

E. A. Mendez, K. B. DeSalvo, Y. Cao, R. F. Garry and L. R. Espinoza

Tulane University Medical and LSU Health Sciences Center, New Orleans, LA 70112-2822, USA

The first 10% of the full text of this article appears below.

SIR, The potential role of retroviruses in the aetiopathogenesis of chronic inflammatory and/or autoimmune disorders has received a great deal of attention over the past few years [1]. Animal retroviruses induce many types of immune dysfunction, including immune deficiencies and autoimmune diseases. For example, caprine arthritis encephalitis virus, a replication-competent lentivirus distantly related to HIV, is the causative agent of chronic arthritis in goats [2]. In addition, defective endogenous retroviruses that are not lentiviruses may also play a role in a mouse model of systemic lupus erythematosus . . . [Full Text of this Article]


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