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Rheumatology 2001; 40: 592-593
© 2001 British Society for Rheumatology

Letters to the Editor

Elevated serum cytokine levels in a rheumatoid arthritis patient with large granular lymphocyte syndrome

M. Ozaki, Y. Kawabe1,, H. Nakamura, K. Migita, A. Kawakami, K. Tsukazaki and K. Eguchi

Nagasaki University, Nagasaki and
1 National Uresino Hospital Fujitu-gun, Saga, Japan

SIR, Large granular lymphocyte (LGL) syndrome [1, 2] is characterized by the proliferation of LGL in the peripheral blood, and is often complicated by neutropenia and rheumatoid arthritis (RA). We experienced a case of RA with LGL clonal expansion. RA activity in this patient was low; neither joint tenderness nor swelling was observed. However, strikingly increased levels of serum cytokines [tumour necrosis factor {alpha} (TNF-{alpha}), interleukin 1ß (IL-1ß), interleukin 2 (IL-2), interleukin 6 (IL-6), interleukin 8 (IL-8), granulocyte colony stimulating factor (G-CSF) . . . [Full Text of this Article]

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