| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Rheumatology 2001; 40: 652-655
© 2001 British Society for Rheumatology
Original Papers |
Thrombosis in Behçet's disease: a retrospective survey from a single UK centre
Department of Rheumatology, Northwick Park Hospital, London and
1 Medical Statistics Unit, London School of Hygiene and Tropical Medicine, London, UK
Objective. To contribute to knowledge of vascular occlusion in Behçet's disease (BD), prevalence and relative risk for thrombosis were ascertained retrospectively in a cohort of Caucasian patients with the disease.
Patients. The study included 73 BD patients (36 males, 37 females, mean age 45±11 yr) attending the Immunology/Rheumatology Department of Northwick Park Hospital. A group of 146 patients without BD, attending the same department, served as a control group.
Results. Thrombosis was more frequent in BD patients than in controls (23/73, 32% vs 7/146, 5%, P<0.001). This was accounted for by a higher prevalence of venous thrombosis in BD patients (18/73, 25% vs 4/146, 3%, P<0.001). Gender-adjusted data revealed an 11-fold risk of developing any thrombosis and a 14-fold risk of developing venous thrombosis in BD. After adjusting for differences in age at first symptoms, male BD patients showed a 6-fold higher risk of vein thrombosis. Males reported more often thrombophlebitis (13/36, 36% vs 0/0, P<0.001), folliculitis (8/36, 22% vs 1/37, 3%, P<0.01) and retinal vasculitis (13/36, 36%, vs 4/37, 11%, P=0.01) than females, in whom arthralgia prevailed (23/37, 62%, vs 12/36, 33%, P=0.01).
Conclusion. In our population, BD confers a 14-fold risk of developing venous thrombosis. The risk is sixfold higher in male BD patients, who fare worse than females with regard to thrombophlebitis, folliculitis and retinal vasculitis.
KEY WORDS: Behçet's disease, Thrombosis, Arthritis, Vasculitis, Sex differences.
Correspondence to: P. R. J. Ames, 75 Canterbury House, Royal Street, London SE17EH, UK.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  N. Tanabe, A. Kimura, S. Amano, O. Okada, Y. Kasahara, K. Tatsumi, M. Takahashi, H. Shibata, M. Yasunami, and T. Kuriyama Association of clinical features with HLA in chronic pulmonary thromboembolism Eur. Respir. J., January 1, 2005; 25(1): 131 - 138. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D H Verity, G R Wallace, R W Vaughan, and M R Stanford Behcet's disease: from Hippocrates to the third millennium Br J Ophthalmol, September 1, 2003; 87(9): 1175 - 1183. [Abstract] [Full Text] [PDF]
|
|