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Rheumatology 2001; 40: 721-723
© 2001 British Society for Rheumatology

Editorial

Extra domain-positive fibronectins in arthritis: wolf in sheep's clothing?

S. Carsons

Division of Rheumatology, Allergy and Clinical Immunology, Winthrop University Hospital, Mineola, New York 11501 and Department of Medicine, School of Medicine, State University of New York at NY Stony Brook, Stony Brook, New York, USA

Twenty years ago, elevated quantities of fibronectin (Fn) were detected in inflammatory synovial fluid and synovial tissue [1–3]. Levels were found to be consistently higher in rheumatoid arthritis (RA), but elevations in synovial fluid Fn were also noted in other inflammatory arthropathies [4]. In contrast, Fn levels in RA plasma were similar to those found in normal human plasma [2, 4, 5].

It is reasonable to hypothesize that the increased amounts of Fn found in inflamed joints serve a reparative and/or anti-inflammatory function as Fn has been demonstrated to play a significant role in wound-healing [6] and the opsonic clearance of inflammatory debris such as collagen and fibrin [7, 8]. Deciphering the function of Fn in arthritis has been complicated by its molecular heterogeneity. For example, the forms of Fn found in plasma and tissue . . . [Full Text of this Article]

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X. Chang, R. Yamada, A. Suzuki, Y. Kochi, T. Sawada, and K. Yamamoto
Citrullination of fibronectin in rheumatoid arthritis synovial tissue
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[Abstract] [Full Text] [PDF]