Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (6)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Shiozawa, K.
Right arrow Articles by Shiozawa, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Shiozawa, K.
Right arrow Articles by Shiozawa, S.
Related Collections
Right arrow Experimental Arthritis
Right arrow Rheumatoid Arthritis
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Rheumatology 2001; 40: 739-742
© 2001 British Society for Rheumatology

Original Papers

Alternatively spliced EDA-containing fibronectin in synovial fluid as a predictor of rheumatoid joint destruction

K. Shiozawa, K. Hino1 and S. Shiozawa,1

Department of Medicine and Rheumatology, Kakogawa Konan Hospital and
1 Department of Medicine and Faculty of Health Science, Kobe University School of Medicine, Kobe, Japan

Objectives. Fibronectin containing the EDA region (EDA+Fn), a molecule important for rheumatoid joint destruction, was measured in relation to the progression of joint destruction in rheumatoid arthritis (RA).

Methods. Total Fn and EDA+Fn were measured by ELISA, and the concentrations of Fn in plasma and synovial fluid were compared prospectively for 2 yr with the progression of joint destruction in 41 knee joints of 37 patients with RA. The extent of joint destruction was assessed by the Larsen score and joint space narrowing in X-ray films taken before and 2 yr after measurement of EDA+Fn.

Results. The concentration of synovial fluid EDA+Fn showed a positive correlation with the progression of joint destruction in RA (r=0.78). While total Fn in synovial fluid also showed a correlation with joint destruction (r=0.54), total Fn and EDA+Fn in plasma showed no correlation with joint destruction. The concentration of synovial fluid EDA+Fn was significantly higher in patients who underwent joint replacement after the measurement of EDA+Fn than in those who did not receive surgery (P<0.029).

Conclusion. Synovial fluid EDA+Fn can be a predictor of subsequent joint destruction in RA.

KEY WORDS: Fibronectin, EDA, Rheumatoid arthritis, Joint destruction, Prognosis.

Correspondence to: S. Shiozawa, Kobe University School of Medicine, Faculty of Health Science, 7-10-2 Tomogaoka, Sumaku, Kobe 654-0142, Japan.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Am. J. Pathol.Home page
S. Abdollahi-Roodsaz, L. A.B. Joosten, M. I. Koenders, B. T. van den Brand, F. A.J. van de Loo, and W. B. van den Berg
Local Interleukin-1-Driven Joint Pathology Is Dependent on Toll-Like Receptor 4 Activation
Am. J. Pathol., November 1, 2009; 175(5): 2004 - 2013.
[Abstract] [Full Text] [PDF]

Home page
 Rheumatology (Oxford)Home page
X. Chang, R. Yamada, A. Suzuki, Y. Kochi, T. Sawada, and K. Yamamoto
Citrullination of fibronectin in rheumatoid arthritis synovial tissue
Rheumatology, November 1, 2005; 44(11): 1374 - 1382.
[Abstract] [Full Text] [PDF]

Home page
 Rheumatology (Oxford)Home page
S. Carsons
Extra domain-positive fibronectins in arthritis: wolf in sheep's clothing?
Rheumatology, July 1, 2001; 40(7): 721 - 723.
[Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.