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Rheumatology 2001; 40: 948-949
© 2001 British Society for Rheumatology

Letters to the Editor

Autoimmune neutropenia, thrombocytopenia and Coombs positivity in a patient with primary Sjögren's syndrome

A. Klepfish, J. Friedman, Y. Schechter1 and A. Schattner

Departments of Medicine and Hematology, Kaplan Medical Center, Rehovot and the Hebrew University-Hadassah School of Medicine, Jerusalem and
1 Rambam Medical Center, Haifa, Israel

SIR, Sicca symptoms are the sine qua non of diagnosis of primary Sjögren's syndrome (pSS). However, extraglandular involvement is common and often causes highly varied manifestations [1], which may precede or overshadow the sicca symptoms and cause significant diagnostic delay. We report a patient who presented with multiple cytopenias and three different autoantibodies directed against blood components due to pSS.

A healthy 40-yr-old woman presented with asymptomatic neutropenia, which was found in a routine blood count. Physical examination was normal. Laboratory tests showed erythrocyte sedimentation rate 9 mm/h, haemoglobin (Hb) 12.2 g/dl (normocytic), white blood cell count . . . [Full Text of this Article]

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