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Rheumatology 2002; 41: 103-106
© 2002 British Society for Rheumatology
Heberden Historical Series |
The story of Takayasu arteritis
Heberden Historical Series/Series Editor: M. Jayson
Department of Internal Medicine, Tokyo Medical & Dental University, Tokyo, Japan
Takayasu arteritis is a chronic vasculitis mainly involving the aorta and its main branches, such as the brachiocephalic, carotid, subclavian, vertebral and renal arteries, as well as the coronary and pulmonary arteries.
It induces clinically varied ischaemic symptoms due to stenotic lesions or thrombus formation, including blindness, cataract and/or retinal haemorrhage, pulselessness, aortic regurgitation and/or congestive heart failure due to dilatation of the ascending aorta. More acute progression causes destruction of the media of the arterial wall, leading to the formation of aneurysms and/or dissecting aneurysm or rupture of the involved arteries [1].
Takayasu arteritis is characterized histologically as ‘panarteritis’, involving all layers of the arterial wall, including intimal fibrous thickening and/or typical atheromatous lesions, destruction of medial smooth muscles and elastic layers, cellular infiltration and collagenous fibrosis in the media and thickened adventitia with cellular infiltration around vasa vosorum [2, 3].
Almost all patients
History of Takayasu arteritis
Before Takayasu
After Takayasu
Summary
References
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