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Rheumatology 2002; 41: 706-708
© 2002 British Society for Rheumatology

Letters to the Editor

The measurement of serum salivary isoamylase as a clinical parameter in Sjögren's syndrome

W. W. I. Kalk, A. Vissink, J. C. J. M. Swaanenburg1, F. K. L. Spijkervet, J. L. N. Roodenburg, H. Bootsma2 and C. G. M. Kallenberg3

Departments of Oral and Maxillofacial Surgery,
1 Pathology and Laboratory Medicine,
2 Rheumatology and
3 Clinical Immunology, University Hospital Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands

SIR, Exocrine gland damage due to chronic autoimmune inflammation in Sjögren's syndrome (SS) can be demonstrated, hypothetically, by an increase in gland-specific enzymes that are released in serum, as an alternative to current diagnostic techniques demonstrating loss of function or change in architecture. Measurement of serum enzymes to estimate glandular damage is not used routinely in SS patients, despite the fact that the major salivary glands contain large amounts of salivary (S) isoamylase and are invariably involved in the disease process of SS [1–3. . . [Full Text of this Article]

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