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Rheumatology 2002; 41: 708-710
© 2002 British Society for Rheumatology

Letters to the Editor

Renal microaneurysms in three cases of hepatitis C virus-related vasculitis

N. Costedoat-Chalumeau, P. Cacoub, T. Maisonobe1, V. Thibault2, P. Cluzel3, M. Gatfosse4, Z. Amoura and J.-C. Piette

Service de Médecine Interne,
1 Laboratoire de neuropathologie,
2 Laboratoire de virologie,
3 Service de radiologie, Centre Hospitalier Universitaire Pitié-Salpêtrière, 47–83 Boulevard de l'Hôpital, 75651 Paris Cedex 13 and
4 Service de Médecine Interne, Centre Hospitalier Général, Rue Gabriel Péri, 77527 Coulommiers Cedex, France

SIR, Numerous extrahepatic manifestations have been associated with hepatitis C virus (HCV), including vasculitis of small vessels, such as mixed cryoglobulinaemia (MC), and diseases of the larger vessels, such as polyarteritis nodosa (PAN) [1]. There is still discussion about whether HCV is responsible for PAN, but the involvement of this virus in MC is well known [2–4].

We report three patients with HCV infection and systemic vasculitis who presented with numerous visceral microaneurysms. We discuss the problem of the type of systemic vasculitis (PAN or MC) that is present and the therapeutic consequences. In all patients, tests for antineutrophil cytoplasmic antibodies, HBV and HIV infection were negative.

Patient 1 was a 45-yr-old . . . [Full Text of this Article]

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