Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (19)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Ho, C. Y.
Right arrow Articles by Lam, C. W. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ho, C. Y.
Right arrow Articles by Lam, C. W. K.
Related Collections
Right arrow Systemic Lupus Erythematosus and Autoimmunity
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Rheumatology 2003; 42: 117-122
© 2003 British Society for Rheumatology

Elevated plasma concentrations of nitric oxide, soluble thrombomodulin and soluble vascular cell adhesion molecule-1 in patients with systemic lupus erythematosus

C. Y. Ho, C. K. Wong, E. K. Li1, L. S. Tam1 and C. W. K. Lam

Department of Chemical Pathology and
1 Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong

Objective. To investigate the correlations among plasma concentrations of nitric oxide (NO), soluble thrombomodulin (sTM) and vascular cell adhesion molecule (sVCAM-1), and whether these three molecules are associated with renal involvement in patients with systemic lupus erythematosus (SLE).

Methods. Plasma NO concentrations of 73 SLE patients (35 with renal disease, RSLE patients; 38 without renal disease, SLE patients) and 28 age- and sex-matched healthy control subjects were measured by the non-enzymatic Griess assay, and sTM and sVCAM-1 by enzyme-linked immunosorbent assay.

Results. In RSLE patients, plasma nitrite concentrations were significantly higher than in control subjects (P=0.009) and correlated positively with plasma sTM, plasma creatinine and urea (all P<0.05). Plasma sTM and sVCAM-1 concentrations were significantly elevated in RSLE and SLE patients (both P<0.0001) compared with controls. Plasma sTM was significantly correlated with plasma sVCAM-1, and both were correlated with plasma creatinine and urea and the SLE Disease Activity Index (all P<0.05).

Conclusion. Elevated plasma NO, sTM, and sVCAM-1 concentrations have significant intercorrelations and are strongly associated with renal involvement in SLE.

KEY WORDS: Systemic lupus erythematosus, Nitric oxide, Thrombomodulin, Vascular cell adhesion molecule, Glomerulonephritis.

Correspondence to: C. W. K. Lam, Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong. E-mail: waikeilam{at}cuhk.edu.hk


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Rheumatology (Oxford)Home page
J. R. Batuca, P. R. J. Ames, M. Amaral, C. Favas, D. A. Isenberg, and J. Delgado Alves
Anti-atherogenic and anti-inflammatory properties of high-density lipoprotein are affected by specific antibodies in systemic lupus erythematosus
Rheumatology, January 1, 2009; 48(1): 26 - 31.
[Abstract] [Full Text] [PDF]

Home page
 LupusHome page
G. Yao, Z. Liu, X Zhang, C. Zheng, H. Chen, C. Zeng, and L. Li
Circulating thrombomodulin and vascular cell adhesion molecule-1 and renal vascular lesion in patients with lupus nephritis
Lupus, August 1, 2008; 17(8): 720 - 726.
[Abstract] [PDF]

Home page
 Rheumatology (Oxford)Home page
C. K. Wong, L. C. W. Lit, L. S. Tam, E. K. Li, and C. W. K. Lam
Elevation of plasma osteopontin concentration is correlated with disease activity in patients with systemic lupus erythematosus
Rheumatology, May 1, 2005; 44(5): 602 - 606.
[Abstract] [Full Text] [PDF]

Home page
 LupusHome page
M J Lewis and D D'Cruz
Adhesion molecules, mycophenolate mofetil and systemic lupus erythematosus
Lupus, March 1, 2005; 14(3_suppl): s17 - s26.
[Abstract] [PDF]

Home page
 LupusHome page
M. Lewis and D. D'Cruz
Adhesion molecules, mycophenolate mofetil and systemic lupus erythematosus
Lupus, January 1, 2005; 14(1_suppl): s17 - s26.
[Abstract] [PDF]

Home page
 LupusHome page
K Dixit and R Ali
Role of nitric oxide modified DNA in the etiopathogenesis of systemic lupus erythematosus
Lupus, February 1, 2004; 13(2): 95 - 100.
[Abstract] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.