Skip Navigation


Rheumatology Advance Access originally published online on July 30, 2003
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
42/10/1234    most recent
keg362v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (5)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Nagler, R. M.
Right arrow Articles by Nahir, A. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Nagler, R. M.
Right arrow Articles by Nahir, A. M.
Related Collections
Right arrow Rheumatoid Arthritis
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Rheumatology 2003; 42: 1234-1241
© 2003 British Society for Rheumatology

Report

Salivary gland involvement in rheumatoid arthritis and its relationship to induced oxidative stress

R. M. Nagler1,2, F. Salameh1,3, A. Z. Reznick2, V. Livshits3 and A. M. Nahir3

1Oral Biochemistry Laboratory and Salivary Clinic, Department of Oral and Maxillofacial Surgery, 2Department of Anatomy and Cell Biology and 3B. Shine Department of Rheumatology, Rambam Medical Center and The Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.

Correspondence to: R. M. Nagler, Department of Oral and Maxillofacial Surgery, Rambau Medical Center, Haifa 31096, Israel. E-mail: nagler{at}tx.technion.ac.il

Objectives. The objective of the present study was to analyse salivary gland and free radical involvement in rheumatoid arthritis (RA).

Methods. Thirty-four consenting RA patients (rheumatoid factor-positive) and 18 healthy controls, matched in age and gender, participated in the study. Plasma and saliva samples were harvested and subjected to compositional analysis and various free radical-related tests.

Results. The mean salivary flow rate was lower in the RA patients than in the control group, whereas all plasma and salivary antioxidants were increased. Mean values of plasma malondialdehyde and ceruloplasmin were higher in the RA patients.

Conclusions. The effects of RA on salivary gland flow rates and antioxidant compositional parameters may be of great importance for the further elucidation of the role of free radicals in RA pathogenesis and for its general diagnosis and evaluation. The demonstrated correlation between the altered salivary parameters and the severity of the disease may indicate that evaluation of the salivary status of RA patients is warranted.

KEY WORDS: Saliva, Antioxidants, Rheumatoid arthritis, Total antioxidant status, Peroxidase, Uric acid, Malondialdehyde, Ceruloplasmin, Creatinine


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.