Skip Navigation


Rheumatology Advance Access originally published online on May 30, 2003
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
42/10/1242    most recent
keg324v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (23)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Hein, G.
Right arrow Articles by Franke, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hein, G.
Right arrow Articles by Franke, S.
Related Collections
Right arrow Osteoarthritis and Cartilage
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Rheumatology 2003; 42: 1242-1246
© 2003 British Society for Rheumatology

Report

Advanced glycation end-products pentosidine and N{epsilon}-carboxymethyllysine are elevated in serum of patients with osteoporosis

G. Hein, R. Wiegand, G. Lehmann, G. Stein and S. Franke

Department of Internal Medicine IV, University of Jena, Germany.

Correspondence to: G. Hein, Friedrich-Schiller-University of Jena, Department of Internal Medicine IV, D-07740 Jena, Germany. E-mail: gert.hein{at}med.uni-jena.de

Objective. To investigate serum levels of the advanced glycation end-products (AGEs) pentosidine and N{epsilon}-carboxymethyllysine (CML) in patients classified into different osteoporosis subgroups according to histomorphometric data.

Method. Serum samples were obtained from 116 osteoporotic patients (34 men, 82 women) classified by bone histomorphometry into subgroups with high turnover (HTO, n = 32), low turnover (LTO, n = 39), normal turnover (NTO, n = 9) and cellular uncoupled osteoporosis (CUO, n = 36). Pentosidine was measured by high-performance liquid chromatography, and CML by a competitive enzyme-linked immunoassay.

Results. The entire osteoporosis group had significantly higher pentosidine and CML serum concentrations than healthy subjects. In contrast to healthy subjects, no correlation between levels of AGEs and age could be found. In subgroups characterized by increased bone resorption (HTO, CUO), serum pentosidine correlated significantly with the histomorphometric marker reflecting osteoclast activity/bone resorption (eroded surface as a percentage of trabecular surface). Moreover, in CUO a strong correlation between pentosidine and the mineral apposition rate was found. Surprisingly, in HTO the levels of CML and percentage of eroded surface were significantly negatively correlated.

Conclusion. AGE-modified proteins may be a cause of disturbed bone remodelling in osteoporosis. Our findings do not support the alternative hypothesis that increased AGEs in serum indicate only a more intensive releasing of AGEs in circumstances of increased bone resorption.

KEY WORDS: Osteoporosis, Advanced glycation end-product, Pentosidine, N{epsilon}-Carboxymethyllysine, Bone formation, Bone resorption, Bone histomorphometry


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Clin. Endocrinol. Metab.Home page
A. V. Schwartz, P. Garnero, T. A. Hillier, D. E. Sellmeyer, E. S. Strotmeyer, K. R. Feingold, H. E. Resnick, F. A. Tylavsky, D. M. Black, S. R. Cummings, et al.
Pentosidine and Increased Fracture Risk in Older Adults with Type 2 Diabetes
J. Clin. Endocrinol. Metab., July 1, 2009; 94(7): 2380 - 2386.
[Abstract] [Full Text] [PDF]

Home page
 JPEN J Parenter Enteral NutrHome page
S. Bengmark
Advanced Glycation and Lipoxidation End Products-Amplifiers of Inflammation: The Role of Food
JPEN J Parenter Enteral Nutr, September 1, 2007; 31(5): 430 - 440.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
J. M. Bohlender, S. Franke, G. Stein, and G. Wolf
Advanced glycation end products and the kidney
Am J Physiol Renal Physiol, October 1, 2005; 289(4): F645 - F659.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.