Rheumatology 2003; 42: 1568-1569
© 2003 British Society for Rheumatology
Letter to the Editor |
Specific autoantibodies of SLE, such as anti-Ku, anti-ribosome Po and anti-membrane DNA autoantibodies, in a case of human African trypanosomiasis
Departments of Internal Medicine and 1Radiology, 2Laboratory of Haematology and 3Laboratory of Immunology, Brugmann University Hospital, Free University of Brussels (ULB), Brussels, Belgium
Correspondence to:
M. P. Guillaume, Department of Internal Medicine, Brugmann University Hospital, 4 place Van Gehuchten, 1020 Brussels, Belgium. E-mail: marie-paule.guillaume@chu-brugmann.be
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SIR, Sleeping sickness due to Trypanosoma brucei gambiense is characterized by an insidious course leading to extensive nervous system involvement. Neurological manifestations correlate with progression from meningitis to encephalitis, although the precise pathogenic mechanisms remain unclear [1]. Numerous autoantibodies, such as nuclear antibodies and antibodies against central nervous system (CNS)-specific antigens have been reported in this condition [2].