Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (5)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Giuggioli, D.
Right arrow Articles by Ferri, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Giuggioli, D.
Right arrow Articles by Ferri, C.
Related Collections
Right arrow Systemic Sclerosis
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Rheumatology 2003; 42: 694-696
© 2003 British Society for Rheumatology

Letters to the Editor

Autologous skin grafting in the treatment of severe scleroderma cutaneous ulcers: a case report

D. Giuggioli, M. Sebastiani, M. Cazzato, A. Piaggesi, G. Abatangelo1 and C. Ferri

Department of Internal Medicine Rheumatology Unit, University of Pisa and 1 Department of Histology, Microbiology and Medical Biotechnologies, University of Padova, Padova, Italy

The first 10% of the full text of this article appears below.

SIR, Systemic sclerosis (SSc) is a connective tissue disease characterized by collagen overproduction by altered fibroblasts and microvascular abnormalities, responsible for both visceral and skin involvement [1]. Vascular alterations lead to several typical manifestations of the disease, such as Raynaud's phenomenon and cutaneous ulcers. The latter are a frequent complication of SSc and are poorly responsive to the common pharmacological treatments. Vasodilator therapy with prostacyclin analogues has been reported to be effective in preventing and/or improving small cutaneous ulcers in some patients [2].

After the pioneering work of Rheinwald and Green in the mid-1970s [3], cultured keratinocyte grafting has become an alternative therapeutic approach to various ulcers (vascular, diabetic, post-traumatic) that are unresponsive to traditional treatments [4, 5. . . [Full Text of this Article]


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Rheumatology (Oxford)Home page
S. Chitale, J. Watson, and A. Herrick
Autologous skin grafting--a limb-saving procedure in a patient with diffuse cutaneous systemic sclerosis
Rheumatology, March 1, 2008; 47(3): 379 - 380.
[Full Text] [PDF]