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Rheumatology 2003; 42: 911-912
© 2003 British Society for Rheumatology

Letters to the Editor

Genetic association analysis of BMP5 as a potential osteoarthritis susceptibility gene

L. Southam, K. Chapman and J. Loughlin

University of Oxford, Institute of Musculoskeletal Sciences, Botnar Research Centre, Oxford, UK

The first 10% of the full text of this article appears below.

SIR, A number of twin-pair and sibling risk studies have revealed a major genetic component to primary osteoarthritis (OA), which best fits into the oligogenic multifactorial class of human diseases [1]. We have linkage mapped an OA susceptibility locus to an 11.4 cM interval at chromosome 6p12.3-q13 in a cohort of 146 affected female sibling pair families ascertained by total hip replacement (female-THR families) for primary OA, with a maximum multipoint LOD score of 4.0 [2]. This interval encompasses the candidate gene BMP5 (6p12.1), which encodes for bone morphogenetic protein 5. BMPs are bone-derived factors . . . [Full Text of this Article]


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