Rheumatology 2004; 43: 108-110
© British Society for Rheumatology 2004; all rights reserved
Case Report |
Interstitial nephritis with infiltration of IgG-kappa positive plasma cells in a patient with Sjögren's syndrome
Departments of Oral Maxillofacial Surgery, 1Pathology and 2Clinical Immunology, University Hospital Groningen, Groningen, The Netherlands
Correspondence to: J. Pijpe, Department of Oral and Maxillofacial Surgery, PO box 30.001, 9700 RB Groningen, The Netherlands. E-mail: j.pijpe@kchir.azg.nl
| The first 10% of the full text of this article appears below. |
SIR, Sjögren's syndrome (SS) is an autoimmune disease involving the exocrine glands. It is characterized by lymphocytic infiltration of the exocrine glands and polyclonal B-cell activation. The main symptoms are dry eyes, dry mouth and fatigue, but a variety of other manifestations can also occur. Interstitial nephritis is the principal renal lesion in SS, and occurs in approximately 10% of the patients [1, 2]. Immunohistology shows infiltration of mainly CD4+ T lymphocytes, comparable with those observed in the salivary glands [3].