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Rheumatology 2004; 43: 108-110
© British Society for Rheumatology 2004; all rights reserved


Case Report

Interstitial nephritis with infiltration of IgG-kappa positive plasma cells in a patient with Sjögren's syndrome

J. Pijpe, A. Vissink, J. E. Van der Wal1 and C. G. M. Kallenberg2

Departments of Oral Maxillofacial Surgery, 1Pathology and 2Clinical Immunology, University Hospital Groningen, Groningen, The Netherlands

Correspondence to: J. Pijpe, Department of Oral and Maxillofacial Surgery, PO box 30.001, 9700 RB Groningen, The Netherlands. E-mail: j.pijpe@kchir.azg.nl

The first 10% of the full text of this article appears below.

SIR, Sjögren's syndrome (SS) is an autoimmune disease involving the exocrine glands. It is characterized by lymphocytic infiltration of the exocrine glands and polyclonal B-cell activation. The main symptoms are dry eyes, dry mouth and fatigue, but a variety of other manifestations can also occur. Interstitial nephritis is the principal renal lesion in SS, and occurs in approximately 10% of the patients [1, 2]. Immunohistology shows infiltration of mainly CD4+ T lymphocytes, comparable with those observed in the salivary glands [3]. . . . [Full Text of this Article]


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