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Rheumatology 2004; 43: 111-112
© British Society for Rheumatology 2004; all rights reserved

Case Report

Opportunistic infection due to unexplained CD4+ lymphocytopenia and associated Sjögren's syndrome

A. Schattner, J. Friedman and Z. Bentwich

Department of Medicine and Immunology Institute, Kaplan Medical Center, Hebrew University-Hadassah School of Medicine, Jerusalem, Israel

Correspondence to: A. Schattner, Hebrew University-Hadassah Medical School Head, Department of Medicine, Kaplan Medical Center, Rehovot 76100, Israel. E-mail: amiMD@clalit.org.il

The first 10% of the full text of this article appears below.

SIR, Patients with primary Sjögren's syndrome (SS) usually present with glandular (sicca) symptoms or systemic manifestations [1]. Immune-mediated cytopenias may occur but are unusual as presenting manifestations [2]. We report a patient with serious opportunistic infection due to severe CD4+ T lymphocytopenia, immune activation markers and a concurrent diagnosis of SS.

A 62-yr-old woman developed progressive headache, nausea and low-grade fever over 4 weeks. On admission, obtundation and Brudzinski's sign were the only notable findings. Chest radiography, ECG, electroencephalogram, head CT and laboratory tests were normal, . . . [Full Text of this Article]


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