Rheumatology Advance Access originally published online on July 16, 2003
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Rheumatology 2004; 43: 43-48
© British Society for Rheumatology 2003; all rights reserved
Clinical |
Serum cortisol reduction and abnormal prolactin and CD4+/CD8+ T-cell response as a result of controlled exercise in patients with rheumatoid arthritis and systemic lupus erythematosus despite unaltered muscle energetics
Sir Joseph Hotung Centre for Musculoskeletal Diseases, St George's Hospital & Medical School, London, UK.
Correspondence to: J. S. Axford, Sir Joseph Hotung Centre for Musculoskeletal Diseases, St George's Hospital & Medical School, Blackshaw Road, London SW17 OQT, UK. E-mail: j.axford{at}sghms.ac.uk
Abstract
Objective. To investigate muscle energetics in patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) and measure serum cortisol, prolactin and CD4+/CD8+ T-cell levels during and after controlled exhaustive exercise.
Methods. Patients with RA (n = 7), patients with SLE (n = 6) and healthy individuals (HI) (n = 10) performed incremental cycle ergometry to the limit of tolerance. Ventilation, oxygen uptake (VO2) and carbon dioxide output were measured and the lactate threshold (LT) was estimated. Serum cortisol, prolactin, CD4+ and CD8+ lymphocyte subset levels were determined at baseline, peak exercise and 1 h after exercise.
Results. Exercise tolerance was reduced in patients with RA and patients with SLE, as reflected by peak VO2 and LT, but muscle energetics were not altered. In RA and SLE, there was significant reduction in cortisol levels at peak (–10%; P = 0.03) and post-exercise times (–36%; P = 0.05). Prolactin varied significantly at peak exercise in HI only (+60%; P = 0.05). There was a significant reduction in CD4+ T cells at peak exercise in RA (–15%; P = 0.02) and SLE patients (–8%; P = 0.04) and an increase after exercise in SLE patients (+11%; P = 0.03). In HI, CD8+ T cells increased significantly (+47%; P = 0.01) at peak exercise, but this was not found in RA and SLE patients. A significant reduction in CD8+ T cells was noted after exercise in SLE patients (–6%; P = 0.05).
Conclusion. RA and lupus patients do not have significantly altered muscle energetics, but have abnormal cortisol, prolactin and CD4+/CD8+ T-cell responses to exercise. Further studies need to be carried out to evaluate whether short bouts of strenuous exercise have detrimental clinical effects.
KEY WORDS: Exercise, Rheumatoid arthritis, Systemic lupus erythematosus, Prolactin, Cortisol, CD4+/CD8+ T cells.
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