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Rheumatology Advance Access originally published online on August 29, 2003
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Rheumatology 2004; 43: 95-99
© British Society for Rheumatology 2003; all rights reserved

Report

Cardiovascular autonomic dysfunction in primary Sjögren's syndrome

László Kovács, Dóra Paprika1, Róbert Takács2, Attila Kardos3, Tamás T. Várkonyi2, Csaba Lengyel2, Attila Kovács, László Rudas1 and Gyula Pokorny

Department of Rheumatology, 1Intensive Care Unit of the 2nd Department of Internal Medicine and Cardiology Centre and 21st Department of Internal Medicine, University of Szeged, Faculty of Medicine, Szeged, Hungary and 3Department of Cardiovascular Medicine, John Radcliffe Hospital, Oxford, UK.

Correspondence to: László Kovács, Department of Rheumatology, Faculty of Medicine, University of Szeged, Kossuth L sgt. 42, 6724 Szeged, Hungary. E-mail: kovl{at}in1st.szote.u-szeged.hu

Objective. To assess the occurrence and clinical significance of a cardiovascular autonomic nervous system dysfunction in primary Sjögren's syndrome (pSS).

Methods. Fifty-one pSS patients participated in this case-control study. Heart rate and blood pressure variability measurements, spontaneous baroreflex sensitivity examinations and cardiovascular reflex tests were performed.

Results. The results of the heart rate and blood pressure variability measurements and also the baroreflex sensitivity parameters of the pSS patients peaked in the lowest percentile ranges of a database on 559 healthy control subjects (P < 0.05). In three of the five cardiovascular reflex tests, the frequencies of abnormal results were significantly higher among the patients than among the controls (P < 0.05), and the median autonomic neuropathy score was also elevated (3 vs 0 in the controls; P < 0.0001).

Conclusion. Signs of an autonomic nervous system dysfunction involving the cardiovascular system can be discerned in the majority of pSS patients.

KEY WORDS: Antireceptor antibody, Autonomic dysfunction, Baroreflex sensitivity, Blood pressure variability, Cardiovascular reflex test, Heart rate variability, Primary Sjögren's syndrome.


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T. Mandl, V. Granberg, J. Apelqvist, P. Wollmer, R. Manthorpe, and L. T. H. Jacobsson
Autonomic nervous symptoms in primary Sjogren's; syndrome
Rheumatology, June 1, 2008; 47(6): 914 - 919.
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