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Rheumatology 2004 43(10):1305-1306; doi:10.1093/rheumatology/keh186
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Rheumatology Vol. 43 No. 10 © British Society for Rheumatology 2004; all rights reserved

Letter to the Editor

Anti-BiP antibody levels in juvenile idiopathic arthritis (JIA)

M. D. Bodman-Smith, M. F. Fife1, H. Wythe1, V. M. Corrigal2, G. S. Panayi2, L. R. Wedderburn3 and P. Woo3

Oncology, St George's Hospital Medical School, 1 Centre for Paediatric Rheumatology, University College London,2 Rheumatology, GKT School of Medicine and3 Rheumatology Unit, Institute of Child Health, University College London, London, UK

Correspondence to: M. D. Bodman-Smith; E-mail: mbodmans@sghms.ac.uk

The first 10% of the full text of this article appears below.

SIR, We have previously described the human heat shock protein BiP (immunoglobulin binding protein; glucose regulated protein 78) as an autoantigen in rheumatoid arthritis [1]. Antibodies to BiP have been described in the serum of RA patients by ourselves and other groups [2, 3] and we have recently described anti-BiP antibodies in the synovial fluid of RA patients and the serum of patients with primary Sjögren's syndrome [3]. Moreover anti-BiP antibodies have been shown to be elevated in animal models of arthritis [1]. The functions . . . [Full Text of this Article]


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