Rheumatology Advance Access originally published online on September 7, 2004
Rheumatology 2004 43(12):1574-1579; doi:10.1093/rheumatology/keh397
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Rheumatology Vol. 43 No. 12 © British Society for Rheumatology 2004; all rights reserved
PAPER |
Health-related quality of life in Italian patients with systemic lupus erythematosus. I. Relationship between physical and mental dimension and impact of age
Division of Rheumatology, Department of Medical and Surgical Sciences, 1 Department of Neuroscience, University of Padua, Padua, 2 Department of Rheumatology, University of Ancona, Ancona and 3 Rheumatology Unit, L. Sacco Hospital, Milan, Italy.
Correspondence to: A. Doria, Cattedra e Divisione di Reumatologia, Dipartimento di Scienze Mediche e Chirurgiche, Via Giustiniani, 2, 35128 Padova, Italy. E-mail: adoria{at}unipd.it
Objective. To examine health-related quality of life (HRQOL) in Italian patients with systemic lupus erythematosus (SLE) and compare it with that of healthy people, and to investigate relationships among different dimensions and subscales of a generic health status measure.
Methods. The Medical Outcomes Study Short Form-36 (SF-36) was applied in a cohort of 126 consecutive SLE patients and 96 healthy controls. At the time of HRQOL testing, all patients underwent clinical and laboratory evaluation.
Results. Both physical (PCS) and mental (MCS) component summary scores of the SF-36 were reduced in patients compared with controls. In SLE great variability in all the subscales was observed. Significant correlations between PCS and MCS and between many different subscales were observed in patients but not in controls. The PCS was higher than MCS more frequently in controls than in SLE patients (81 vs 48.4%, P<0.00001). In SLE, HRQOL tended to worsen with age.
Conclusion. Both PCS and MCS contribute to the decrease in HRQOL in SLE patients. In SLE the mutual interaction between these two dimensions seems to be more relevant than in healthy people.
KEY WORDS: SF-36, Health-related quality of life, Mental health, Physical health, Systemic lupus erythematosus
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