Skip Navigation


Rheumatology Advance Access originally published online on December 16, 2003
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
43/3/294    most recent
keh058v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (36)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Hernández-Rodríguez, J.
Right arrow Articles by Cid, M. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hernández-Rodríguez, J.
Right arrow Articles by Cid, M. C.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Rheumatology 2004; 43: 294-301
Rheumatology Vol. 43 No. 3 (c) British Society for Rheumatology 2003; all rights reserved

Basic Science

Tissue production of pro-inflammatory cytokines (IL-1ß, TNF{alpha} and IL-6) correlates with the intensity of the systemic inflammatory response and with corticosteroid requirements in giant-cell arteritis

J. Hernández-Rodríguez, M. Segarra, C. Vilardell, M. Sánchez1, A. García-Martínez, M. J. Esteban, C. Queralt, J. M. Grau, A. Urbano-Márquez, A. Palacín1, D. Colomer2 and M. C. Cid

Vasculitis Research Unit, Department of Internal Medicine, 1Pathology and 2Hematopathology, Hospital Clínic, University of Barcelona, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.

Correspondence to: M. C. Cid, Department of Internal Medicine, Hospital Clínic, Villarroel 170, 08036 Barcelona, Spain. E-mail: mccid{at}clinic.ub.es

Objectives. To investigate proinflammatory cytokine expression in temporal arteries from patients with giant-cell arteritis (GCA) and to analyse its relationship with the intensity of the initial systemic inflammatory reaction and response to corticosteroid therapy.

Methods. Quantification of interleukin-1ß (IL-1ß), tumor necrosis factor {alpha} (TNF{alpha}), and interleukin-6 (IL-6) mRNA by real-time quantitative PCR in temporal artery samples from 36 patients with biopsy-proven GCA and 11 controls. Immunohistochemical detection of IL-1ß, TNF{alpha}, and IL-6 in temporal artery sections from 74 patients with GCA and 15 controls. Clinical and biochemical parameters of inflammation as well as the time (weeks) required to reach a maintenance prednisone dose <10 mg/day were recorded.

Results. IL-1ß (13.8 ± 2.5 vs 5.4 ± 1.3 relative units, P = 0.012) and IL-6 transcripts (34 ± 13.7 vs 7.8 ± 4.5 relative units, P = 0.034) were significantly more abundant in patients with a strong systemic inflammatory response compared with those with no inflammatory parameters. Immunohistochemical scores for IL-1ß (2.7 ± 0.3 vs 1.9 ± 0.2, P = 0.018), TNF{alpha} (3.2 ± 0.2 vs 2.4 ± 0.3, P = 0.028) and IL-6 (3 ± 0.2 vs 2.1 ± 0.3, P = 0.023) were also significantly higher in patients with strong systemic inflammatory reaction. A significant correlation was found between the amount of tissue TNF{alpha} mRNA and the time required to reach a maintenance dose of prednisone <10 mg/day (r = 0.586, P = 0.001).

Conclusion. GCA patients with a strong systemic inflammatory response, who have been previously shown to be more resistant to corticosteroid therapy, have elevated tissue expression of proinflammatory cytokines IL-1ß, TNF{alpha} and IL-6. High production of TNF{alpha} is associated with longer corticosteroid requirements.

KEY WORDS: Giant-cell arteritis, Vasculitis, Inflammation, Cytokines, Acute phase response.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 The Journal of RheumatologyHome page
R. PALOMINO-MORALES, O. TORRES, T. R. VAZQUEZ-RODRIGUEZ, I. C. MORADO, S. CASTANEDA, J. L. CALLEJAS-RUBIO, J. A. MIRANDA-FILLOY, B. FERNANDEZ-GUTIERREZ, J. MARTIN, and M. A. GONZALEZ-GAY
Association Between Toll-like Receptor 4 Gene Polymorphism and Biopsy-proven Giant Cell Arteritis
J Rheumatol, July 1, 2009; 36(7): 1501 - 1506.
[Abstract] [Full Text] [PDF]

Home page
 ANN INTERN MEDHome page
C. Salvarani and G. G. Hunder
Tumor Necrosis Factor Blocking Agents in Polymyalgia Rheumatica and Giant Cell Arteritis
Ann Intern Med, January 15, 2008; 148(2): 167 - 168.
[Full Text] [PDF]

Home page
 Ann Rheum DisHome page
M. Segarra, A. Garcia-Martinez, M. Sanchez, J. Hernandez-Rodriguez, E. Lozano, J. M Grau, and M. C Cid
Gelatinase expression and proteolytic activity in giant-cell arteritis
Ann Rheum Dis, November 1, 2007; 66(11): 1429 - 1435.
[Abstract] [Full Text] [PDF]

Home page
 ANN INTERN MEDHome page
G. S. Hoffman, M. C. Cid, K. E. Rendt-Zagar, P. A. Merkel, C. M. Weyand, J. H. Stone, C. Salvarani, W. Xu, S. Visvanathan, M. U. Rahman, et al.
Infliximab for Maintenance of Glucocorticosteroid-Induced Remission of Giant Cell Arteritis: A Randomized Trial
Ann Intern Med, May 1, 2007; 146(9): 621 - 630.
[Abstract] [Full Text] [PDF]

Home page
 ANN INTERN MEDHome page
C. Salvarani, P. Macchioni, C. Manzini, G. Paolazzi, A. Trotta, P. Manganelli, M. Cimmino, R. Gerli, M. G. Catanoso, L. Boiardi, et al.
Infliximab plus Prednisone or Placebo plus Prednisone for the Initial Treatment of Polymyalgia Rheumatica: A Randomized Trial
Ann Intern Med, May 1, 2007; 146(9): 631 - 639.
[Abstract] [Full Text] [PDF]

Home page
 ANN INTERN MEDHome page
R. Luqmani
Treatment of Polymyalgia Rheumatica and Giant Cell Arteritis: Are We Any Further Forward?
Ann Intern Med, May 1, 2007; 146(9): 674 - 676.
[Full Text] [PDF]

Home page
 Rheumatology (Oxford)Home page
M. C. Cid, M. P. Hoffman, J. Hernandez-Rodriguez, M. Segarra, M. Elkin, M. Sanchez, C. Vilardell, A. Garcia-Martinez, M. Pla-Campo, J. M. Grau, et al.
Association between increased CCL2 (MCP-1) expression in lesions and persistence of disease activity in giant-cell arteritis
Rheumatology, November 1, 2006; 45(11): 1356 - 1363.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.