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Rheumatology 2004 43(9):1194-1195; doi:10.1093/rheumatology/keh279
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Rheumatology Vol. 43 No. 9 © British Society for Rheumatology 2004; all rights reserved

Letter to the Editor

Non-musculoskeletal symptoms in joint hypermobility syndrome. Indirect evidence for autonomic dysfunction?

A. J. Hakim1,2 and R. Grahame1

1 Centre for Rheumatology, University College London Hospitals and 2 Academic Rheumatology and Osteoporosis Unit, Whipps Cross University Hospital, London, UK

Correspondence to: A. J. Hakim, Whipps Cross University Hospital, Leytonstone, London E11 1NR, UK. E-mail: alanhakim@aol.com

The first 10% of the full text of this article appears below.

SIR, Joint hypermobility syndrome (JHS) is a chronically disabling disorder manifested as widespread pain, fatigue, multiple soft tissue lesions and fragility of skin and supportive connective tissues [1]. It is a condition that is often overlooked by clinicians [2]. Moreover, clinical experience suggests that previously unrecognized non-musculoskeletal symptoms, including presyncope, palpitations and bowel disturbance, are also common in JHS. Recent evidence demonstrates dysfunction of the autonomic nervous system as an explanation for these symptoms [3]. Recognition of these symptoms by clinicians . . . [Full Text of this Article]


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