Rheumatology Advance Access originally published online on October 5, 2004
Rheumatology 2005 44(1):120-125; doi:10.1093/rheumatology/keh421
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Rheumatology Vol. 44 No. 1 © British Society for Rheumatology 2004; all rights reserved
PAPER |
Relationship between growth hormone–IGF-I–IGFBP-3 axis and serum leptin levels with bone mass and body composition in patients with rheumatoid arthritis
Department of Rheumatology and 1 Department of Physiology, University Hospital Jean Minjoz, Bd Fleming, 25030 Besançon and 2 Department of Dermatology, St Jacques Hospital, Place St Jacques, 25030 Besançon, France.
Correspondence to: E. Toussirot, Department of Rheumatology, University Hospital Jean Minjoz, Bd Fleming, 25030 Besançon cedex, France. E-mail: eric.toussirot{at}ufc-chu.univ-fcomte.fr
Objectives. Hormonal factors playing a role in bone mass and body composition have been rarely assessed in rheumatoid arthritis (RA). In this study, we aimed to evaluate the growth hormone (GH)–insulin-like growth factor-I (IGF-I)–insulin-like growth factor binding protein-3 (IGFPB-3) axis and serum leptin levels in patients with RA and to determine whether these hormonal/growth factors may influence bone mass and body composition in RA.
Methods. Serum GH, IGF-I, IGFPB-3 and leptin were evaluated in 38 corticosteroid-treated RA patients, 14 non-RA patients under corticosteroids (corticosteroid controls, CC) and 32 healthy controls (HC). Bone density was evaluated using dual X-ray absorptiometry (DEXA), and expressed as bone mineral density (BMD), and quantitative ultrasound (QUS). Body composition was assessed by DEXA.
Results. The three groups differed regarding femoral neck, total body BMD, lean mass and QUS parameters with lower values in the RA group (all P 
0.05). Growth hormone was higher in RA patients (P = 0.0001) while IGF-I and IGFBP-3 did not differ between the three groups. In RA patients there was a tendency to high serum leptin levels and leptin strongly correlated with fat mass (r = 0.83, P<0.0001), but not with bone mass measurements or inflammatory parameters. There were no differences for lean mass, GH and leptin between CC and HC.
Conclusion. Our results suggest that these GH and leptin modifications could have an influence on both bone mass and body composition in RA.
KEY WORDS: Bone mineral density, Bone metabolism, Leptin, Growth hormone, Insulin-like growth factors
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  C. Clapp, S. Thebault, M. C. Jeziorski, and G. Martinez De La Escalera Peptide Hormone Regulation of Angiogenesis Physiol Rev, October 1, 2009; 89(4): 1177 - 1215. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. D. Summers, C. M. Deighton, M. J. Rennie, and A. H. Booth Rheumatoid cachexia: a clinical perspective Rheumatology, August 1, 2008; 47(8): 1124 - 1131. [Abstract] [Full Text] [PDF]
|
|