Rheumatology Advance Access originally published online on July 5, 2005
Rheumatology 2005 44(10):1294-1298; doi:10.1093/rheumatology/kei010
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The 158V polymorphism of Fc gamma receptor type IIIA in early rheumatoid arthritis: increased susceptibility and severity in male patients (the Swedish TIRA* project)
1 Division of Rheumatology, Department of Molecular and Clinical Medicine and 2 Division of Cell Biology, Department of Biochemistry and Surgery, Faculty of Health Sciences, Linköping University, Sweden.
Correspondence to: A. Kastbom, Division of Rheumatology/AIR, Linköping University Hospital, SE-58185 Linköping, Sweden. E-mail: alfka739{at}student.liu.se
Objectives. To evaluate the influence of Fc
receptor IIIA (FcRIIIA) 158V/F polymorphism on susceptibility and disease severity in early rheumatoid arthritis (RA).
Methods. In 181 Swedish patients (128 women, 53 men) with RA of recent onset, disease and disability variables such as erythrocyte sedimentation rate, 28-joint disease activity score (DAS28) and health assessment questionnaire (HAQ) scores were monitored regularly during 3 yr. Three hundred and sixty-two controls were recruited from the same geographical area as the patients. FcRIIIA genotyping was performed using denaturing high-performance liquid chromatography.
Results. In all RA patients, FcRIIIA-158VV was significantly over-represented compared with controls [odds ratio (OR) 1.9, 95% confidence interval (CI) 1.01–3.5, P<0.05]. After stratifying for sex, the difference remained in the male population (OR 3.2, 95%CI 1.03–11, P<0.05) but disappeared among women (OR 1.4, 95%CI 0.7–3.1, P=0.4). In addition, 158VV patients were more likely to exhibit early joint erosions (OR 6.1, 95%CI 1.4–28, P<0.01). At baseline, patients with different FcRIIIA genotypes did not differ with respect to measures of disease activity or functional ability. Thereafter, in male patients with at least one V allele the mean DAS28 and HAQ scores were higher compared with 158FF. In contrast, female patients with at least one 158V allele displayed lower mean DAS28 and HAQ scores compared with those with 158FF.
Conclusions. In a male population, the FcRIIIA-158VV genotype is associated with an increased risk of developing RA, and the 158V allele with more severe disease in early RA.
KEY WORDS: Disease course, Early rheumatoid arthritis, Fc receptor, Single-nucleotide polymorphism
*TIRA is a Swedish acronym for ‘early invention in rheumatoid arthritis’ and is a multicentre cooperation between rheumatology units in southeastern Sweden.
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