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Rheumatology Advance Access originally published online on January 5, 2005
Rheumatology 2005 44(3):406-408; doi:10.1093/rheumatology/keh479
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Rheumatology Vol. 44 No. 3 © British Society for Rheumatology 2005; all rights reserved

LETTER TO THE EDITOR

Anakinra for flares of pyogenic arthritis in PAPA syndrome

M. P. Dierselhuis, J. Frenkel1, N. M. Wulffraat1 and J. J. Boelens1

Department of Pediatric Immunology and Rheumatology and 1 Department of General Pediatrics, Wilhelmina Children's Hospital, University Medical Center Utrecht, Suite 03.063.0, P.O. Box 85090, 3580AB, Utrecht, The Netherlands

Correspondence to: J.J. Boelens. E-mail: j.j.boelens@wkz.azu.nl

The first 10% of the full text of this article appears below.

SIR, Pyogenic arthritis, pyoderma gangrenosum and acne (PAPA) syndrome (MIM no. 604416 [OMIM] ) is an autosomal dominant autoinflammatory disease caused by mutations in the PTSTPIP gene [1]. Historically, it had been described as streaking leucocyte factor disease [2]. PAPA syndrome is characterized by recurrent sterile arthritis that usually occurs after minor trauma, but also spontaneously [3]. It is a self-limiting disease, but can lead to serious joint destruction. No effective treatment has been published so far, . . . [Full Text of this Article]


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