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Rheumatology Advance Access originally published online on February 16, 2005
Rheumatology 2005 44(4):426-433; doi:10.1093/rheumatology/keh530
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Rheumatology Vol. 44 No. 4 © British Society for Rheumatology 2005; all rights reserved

REVIEW

Predictive and potentially predictive factors in early arthritis: a multidisciplinary approach

P. Härle, T. Bongartz, J. Schölmerich, U. Müller-Ladner and R. H. Straub

Laboratory of Neuroendocrinoimmunology, Department of Internal Medicine I, University Hospital Regensburg, Regensburg, Germany.

Correspondence to: R. H. Straub, Department of Internal Medicine I, University Hospital, 93042 Regensburg, Germany. E-mail: rainer.straub{at}klinik.uni-r.de

Objectives. Rheumatoid arthritis (RA) is characterized by variable degrees of joint inflammation, joint destruction, progressive disability and premature death. Destruction of joint cartilage and bone may occur early during disease, as was shown in longitudinal studies of RA, and there is increasing consent among rheumatologists that early diagnosis and early initiation of therapy with disease-modifying anti-rheumatic drugs (DMARDs) can limit the severity of RA. Unfortunately, the currently used diagnostic and predictive indicators (clinical, laboratory and radiological) are of limited value for making an early diagnosis and prognosis of the disease course at the individual level, thus reducing optimal benefit from present and emerging therapies. Therefore, this review focuses on the multidisciplinary aspects of neuroendocrine–immune changes in RA.

Methods. A Medline search was performed using the search terms ‘androgens’, ‘estrogens’, ‘sympathetic nervous system’, ‘sensory nervous system’, ‘prognosis’, ‘early rheumatoid arthritis’, ‘arthritis’ and ‘studies’ in various combinations. For the tabular overview, we only listed clinical studies focusing on endocrine and neuronal aspects.

Results. In addition to the currently used predictive indicators, there is an abundant body of literature describing changes of the neuronal, endocrine and immune parameters during inflammatory diseases. Unfortunately, no longitudinal studies concerning neuroendocrine aspects have been done up to now.

Conclusion. Parameters of the neuroendocrine system should be included in anticipated longitudinal clinical studies to find their true predictive value in early RA.

KEY WORDS: Immune system, Endocrine system, Nervous system, Prognosis, Early rheumatoid arthritis


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