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Rheumatology Advance Access originally published online on November 15, 2005
Rheumatology 2006 45(1):113-114; doi:10.1093/rheumatology/kei148
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© The Author 2005. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

LETTER TO THE EDITOR

Evidence for a differential association of the Arg200Trp single-nucleotide polymorphism in FRZB with hip osteoarthritis and osteoporosis

R. J. Lories1, S. Boonen2, J. Peeters1, K. de Vlam1 and F. P. Luyten1,2

1 Laboratory for Skeletal Development and Joint Disorders, Department of Rheumatology and 2 Leuven University Center for Metabolic Bone Diseases, University Hospitals Leuven, Katholieke Universiteit Leuven, Belgium

Correspondence to: F. P. Luyten, Department of Rheumatology, University Hospitals Leuven, Herestraat 49, B-3000 Leuven, Belgium. E-mail: Frank.Luyten@uz.kuleuven.ac.be

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SIR, Osteoarthritis and osteoporosis are disabling diseases in the elderly. Clinical observations suggest an inverse relationship between these disorders (for review see [1]). This hypothesis is still controversial and no molecular basis for this observation has been demonstrated. Genome-wide linkage analysis and subsequent association study identified a single-nucleotide polymorphism (SNP) (Arg324Gly) in the frizzled-related protein (FRZB) gene associated with hip osteoarthritis in Caucasian females [2] and with generalized osteoarthritis at multiple sites in Caucasians [3]. The haplotype coding for substitutions of . . . [Full Text of this Article]


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