Skip Navigation


Rheumatology Advance Access originally published online on December 13, 2005
Rheumatology 2006 45(2):229-230; doi:10.1093/rheumatology/kei196
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Supplementary data
Right arrow All Versions of this Article:
45/2/229    most recent
kei196v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (3)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Perry, M. G.
Right arrow Articles by Kirwan, J. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Perry, M. G.
Right arrow Articles by Kirwan, J. R.
Related Collections
Right arrow Rheumatoid Arthritis
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2005. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

LETTER TO THE EDITOR

Sequential synovial fluid sampling suggests plasma and synovial fluid IL-6 vary independently in rheumatoid arthritis

M. G. Perry, L. Richards1, M. S. Harbuz1, D. S. Jessop1 and J. R. Kirwan

Academic Rheumatology, University of Bristol, Bristol Royal Infirmary and 1 Henry Wellcome Laboratories for Integrated Neuroscience and Endocrinology, University of Bristol, Bristol, UK

Correspondence to: M. G. Perry, Academic Rheumatology Unit, Bristol Royal Infirmary, Marlborough Street, Bristol BS2 8HW, UK. E-mail: mark.g.perry@bristol.ac.uk

The first 10% of the full text of this article appears below.

SIR, Inflammatory cytokines, including interleukin-6 (IL-6), are raised in rheumatoid arthritis (RA). Single paired daytime samples show that the IL-6 and TNF-{alpha} concentrations in synovial fluid exceed blood concentrations during the day [1–3], and these and other data suggest that joints are the source. Recent data have shown that plasma IL-6 in RA follows a circadian pattern with a peak at 6 a.m. [4]. If IL-6 is generated inside joints and diffuses into plasma, it might be expected that the synovial fluid IL-6 concentration . . . [Full Text of this Article]


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?