Skip Navigation


Rheumatology Advance Access originally published online on January 31, 2006
Rheumatology 2006 45(7):815-818; doi:10.1093/rheumatology/kel012
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
45/7/815    most recent
kel012v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (6)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Ogawa, F.
Right arrow Articles by Sato, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ogawa, F.
Right arrow Articles by Sato, S.
Related Collections
Right arrow Systemic Sclerosis
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2006. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Serum levels of 8-isoprostane, a marker of oxidative stress, are elevated in patients with systemic sclerosis

F. Ogawa, K. Shimizu, E. Muroi, T. Hara, M. Hasegawa1, K. Takehara1 and S. Sato

Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki and 1 Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan.

Correspondence to: S. Sato, Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, 1–7–1 Sakamoto, Nagasaki 852-8501, Japan. E-mail: s-sato{at}net.nagasaki-u.ac.jp

Objective. To determine serum levels and clinical correlation of 8-isoprostane, which is produced in vivo through free radical-catalysed peroxidation of arachidonic acid and reflects oxidative stress, in patients with systemic sclerosis (SSc).

Methods. Serum 8-isoprostane levels from 32 patients with diffuse cutaneous SSc (dSSc) and 25 patients with limited cutaneous SSc (lSSc) were examined by enzyme-linked immunosorbent assay.

Results. Serum 8-isoprostane levels were elevated in dSSc and lSSc patients by 75-fold compared with normal controls (n=32). Serum 8-isoprostane levels correlated negatively with pulmonary function, such as percentage vital capacity and diffusion capacity for carbon monoxide, and correlated positively with renal vascular damage determined by colour flow Doppler ultrasonography. Serum 8-isoprostane levels also correlated positively with serum levels of IgG and anti-agalactosyl IgG autoantibody.

Conclusion. Increased 8-isoprostane levels correlated with the severity of pulmonary fibrosis, the extent of renal vascular damage and immunological abnormalities in SSc, suggesting that enhanced oxidative stress is related to the development of SSc.

KEY WORDS: Systemic sclerosis, Oxidative stress, 8-isoprostane, Pulmonary fibrosis, Renal vascular damage, Immunological abnormalities


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Rheumatology (Oxford)Home page
A. Dooley, S. Y. Low, A. Holmes, A. G. Kidane, D. J. Abraham, C. M. Black, and K. R. Bruckdorfer
Nitric oxide synthase expression and activity in the tight-skin mouse model of fibrosis
Rheumatology, March 1, 2008; 47(3): 272 - 280.
[Abstract] [Full Text] [PDF]

Home page
 Ann Rheum DisHome page
A Servettaz, P Guilpain, C Goulvestre, C Chereau, C Hercend, C Nicco, L Guillevin, B Weill, L Mouthon, and F Batteux
Radical oxygen species production induced by advanced oxidation protein products predicts clinical evolution and response to treatment in systemic sclerosis
Ann Rheum Dis, September 1, 2007; 66(9): 1202 - 1209.
[Abstract] [Full Text] [PDF]

Home page
 Rheumatology (Oxford)Home page
Y. Iwata, F. Ogawa, K. Komura, E. Muroi, T. Hara, K. Shimizu, M. Hasegawa, M. Fujimoto, Y. Tomita, and S. Sato
Autoantibody against peroxiredoxin I, an antioxidant enzyme, in patients with systemic sclerosis: possible association with oxidative stress
Rheumatology, May 1, 2007; 46(5): 790 - 795.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.