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Rheumatology Advance Access originally published online on March 10, 2006
Rheumatology 2006 45(7):911-912; doi:10.1093/rheumatology/kei129
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© The Author [2006]. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

LETTER TO THE EDITOR

Treatment of severe Raynaud's phenomenon with bosentan in a patient with systemic sclerosis

J. Dunne1,2, J. Dutz2, K. Shojania2, B. Ng3 and S. van Eeden1,2,3

1 Department of Medicine, St Paul's Hospital, 2 University of British Columbia, 3 Capture Centre for Cardiovascular and Pulmonary Research, Vancouver, BC, Canada

The first 10% of the full text of this article appears below.

SIR, Raynaud's phenomenon is characterized by recurrent episodes of vasospasm most commonly occurring in the hands and feet. It is a manifestation of the widespread vascular involvement that occurs in systemic sclerosis [1]. Digital ischaemic and necrotic lesions are a frequent complication, with an estimated frequency of 30–40% [2. . . [Full Text of this Article]


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