© The Author 2006. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Novel aspects in the epidemiology, pathophysiology and treatment of connective tissue diseases
Department of Rheumatology, University Hospital Zurich, Switzerland and 1Department of Rheumatology and Clinical Immunology, University of Giessen and Marburg, Kerckhoff Clinic Bad Nauheim, Germany.
Correspondence to: O. Distler, MD, Department of Rheumatology, University Hospital Zurich, Gloriastr. 25, 8091 Zurich, Switzerland. E-mail: Oliver.Distler@usz.ch
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The past decade has been marked by rapid advances in molecular biology techniques, which are now routinely and commercially available for research groups around the world. Examples include the microarray technique and methods for gene silencing such as small interference RNA (siRNA) and cell transfection with anti-sense constructs. For research groups interested in the pathogenesis of certain diseases, these novel techniques allow a rapid high throughput screening for genes which are differentially expressed in health and disease, and might thus be of functional importance for disease development