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Rheumatology Advance Access originally published online on September 12, 2007
Rheumatology 2007 46(10):1547-1550; doi:10.1093/rheumatology/kem224
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© The Author 2007. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Lack of association of the –463 G/A myeloperoxidase promoter polymorphism with Behçet's disease in Italian patients

F. Atzeni, L. Boiardi1, B. Casali2, E. Farnetti2, P. Sarzi-Puttini, N. Pipitone1, I. Olivieri3, F. Cantini4, F. Salvi5, R. La Corte6, G. Triolo7, D. Filippini8, G. Paolazzi9 and C. Salvarani1

Unità di Reumatologia, Ospedale L. Sacco, Milano, 1Unità di Reumatologia, 2Laboratorio di Biologia Molecolare, Arcispedale S. Maria Nuova, Reggio Emilia, 3Unità di Reumatologia, Ospedale S. Carlo, Potenza, 4Unità di Reumatologia, Ospedale Misericordia e Dolce, Prato, 5Dipartimento Scienze Neurologiche, Ospedale Bellaria, Bologna, 6Cattedra di Reumatologia, Università di Ferrara, Ferrara, 7Cattedra Reumatologia, Università di Palermo, 8Unità di Reumatologia, Ospedale Niguarda, Milano and 9Unità di Reumatologia, Ospedale Santa Chiara, Trento, Italy.

Correspondence to: Dr Carlo Salvarani, Servizio di Reumatologia, Arcispedale S. Maria Nuova, V.le Risorgimento N80, 42100 Reggio Emilia, Italy. E-mail: salvarani.carlo{at}asmn.re.it


  Abstract

Objective. To investigate potential associations between the –463 G/A myeloperoxidase (MPO) promoter polymorphism and susceptibility to, and clinical expression of, Behçet's disease (BD).

Methods. One hundred and seventy-five Italian patients who satisfied the International Study Group criteria for BD and 235 healthy age- and sex-matched blood donors were genotyped for the –463 G/A promoter polymorphism of the MPO gene by molecular methods. The patients were subgrouped according to the presence or absence of clinical manifestations.

Results. The distribution of allele and genotype frequencies of the MPO –463A/G polymorphism did not differ significantly between the BD patients and the healthy controls. Carriers of the –463 A allele (A/A or A/G) [odds ratio (OR) 0.7, 95% confidence interval (CI) 0.5–1.1] and homozygosity for A allele (OR 0.3, 95% CI 0.1–1.3) were less frequent among BD patients than among the controls, but the difference was not statistically significant. No significant associations were found when BD patients with and those without clinical manifestations were compared.

Conclusion. Our data suggest that the –463 G/A promoter polymorphism of the MPO gene is not associated with susceptibility to, and clinical expression of, BD in Italian patients.

KEY WORDS: Behçet's disease, Myeloperoxidase gene polymorphism, Myeloperoxidase, Disease manifestation

Submitted 28 April 2007; revised version accepted 17 July 2007.
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