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Rheumatology Advance Access originally published online on April 2, 2007
Rheumatology 2007 46(6):907-910; doi:10.1093/rheumatology/kem040
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© The Author 2007. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

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Vasculopathy and arterial stenotic lesions in the antiphospholipid syndrome

C. Christodoulou, S. Sangle and D. P. D'Cruz

The Lupus Research Unit, The Rayne Institute, St Thomas’ Hospital, London, UK.

Correspondence to: David D’Cruz, The Lupus Research Unit, The Rayne Institute, St Thomas’ Hospital, London, SE1 7EH, UK, E-mail: david.d'cruz{at}kcl.ac.uk


  Abstract

The antiphospholipid (Hughes) syndrome (APS) is characterized by recurrent arterial or venous thromboembolism, or pregnancy loss, in association with antiphospholipid antibodies. These antibodies may be associated with premature or accelerated atherosclerosis and emerging evidence supports the concept of a vasculopathy in the APS that may lead to arterial stenotic lesions, possibly contributing to vascular occlusions and pregnancy morbidity.

KEY WORDS: Antiphospholipid syndrome, Vasculopathy, Atherosclerosis, Stenotic lesions, Intima media thickness

Submitted 2 October 2006; revised version accepted 24 January 2007.
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