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Rheumatology Advance Access originally published online on May 3, 2007
Rheumatology 2007 46(7):1076-1078; doi:10.1093/rheumatology/kem099
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© The Author 2007. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Mannose-binding lectin gene polymorphisms in a cohort study of ANCA-associated small vessel vasculitis

L. Kamesh1, J. M. Heward2, J. M. Williams1, S. C. L. Gough2, C. O. S. Savage1 and L. Harper1

1Division of Infection and Immunity and 2Division of Medical Sciences, Medical School, University of Birmingham B15 2TT, UK.

Correspondence to: Lorraine Harper, Division of Immunity and Infection, The Medical School, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK. E-mail: l.harper{at}bham.ac.uk


  Abstract

Objective. To investigate whether single nucleotide polymorphisms (SNPs) within the mannose-binding lectin (MBL) gene are associated with small vessel vasculitis (SVV) and are a risk factor for intercurrent infection, as described previously in other autoimmune diseases.

Methods. Six SNPs in the MBL promoter and coding region were genotyped by sequence-specific polymerase chain reaction or restriction fragment length polymorphism assay in 170 white Caucasians with SVV and 372 ethnically matched controls in a case-control association study. Serum MBL levels were measured by ELISA. The genotype and protein concentrations were correlated to clinical details retrieved from hospital records.

Results. No differences in allelic and genotypic frequencies were detected between patients with SVV and control subjects. MBL deficiency did not increase the susceptibility to infection (P = 0.6, Fisher's exact test) or the duration of hospital stay.

Conclusion. Our data suggest that MBL polymorphisms are not associated with SVV and do not influence the incidence of concomitant infections. These results raise doubts about the usefulness of MBL polymorphisms as a predictive marker for infection in SVV.

KEY WORDS: Vasculitis, Infection, Polymorphisms, Immunocompromised, Auto antibody, ANCA

Submitted 7 January 2007; revised version accepted 22 March 2007.
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