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Rheumatology Advance Access originally published online on July 21, 2007
Rheumatology 2007 46(9):1428-1432; doi:10.1093/rheumatology/kem160
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© The Author 2007. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

The anti-allergic drug, N-(3',4'-dimethoxycinnamonyl) anthranilic acid, exhibits potent anti-inflammatory and analgesic properties in arthritis

J. J. Inglis, G. Criado, M. Andrews, M. Feldmann, R. O. Williams{dagger} and M. L. Selley1,{dagger}

Kennedy Institute of Rheumatology, Imperial College London, London W6 8LH, UK and 1Pacific Therapeutics, Level 31, ABN AMRO Tower, 88 Philip Street, Sydney, NSW 2000, Australia.

Correspondence to: Richard Williams, Kennedy Institute of Rheumatology Division, Imperial College London, London W6 8LH, UK. E-mail: richard.o.williams{at}imperial.ac.uk.


  Abstract

Objectives. The degradation of tryptophan by indoleamine 2,3-dioxygenase yields a number of immunomodulatory metabolites, including 3-hydroxyanthranilic acid, 3-hydroxykynurenic acid and quinolinic acid. N-(3',4'-dimethoxycinnamonyl) anthranilic acid (3,4-DAA) is a synthetic anthranilic acid derivative that has been used therapeutically in Japan for many years as an anti-allergic drug and has recently been shown to be effective in a murine model of multiple sclerosis.

Methods. In the present study, we tested the efficacy of 3,4-DAA in collagen-induced arthritis, a mouse model of rheumatoid arthritis, and analysed its mechanism of action.

Results. Administration of 3,4-DAA after arthritis onset reduced clinical and histological severity of arthritis and reduced pain. It completely abrogated thermal and mechanical hyperalgesia. 3,4-DAA also suppressed Th1 cell activity in lymph node cell cultures and raised serum levels of IL-10. In vitro, 3,4-DAA suppressed IFN{gamma} production and proliferation of both T and B lymphocytes in a manner comparable with the endogenous tryptophan metabolite, 3-hydroxyanthranilic acid, suggesting similar mechanisms of action.

Conclusion. It is concluded that 3,4-DAA has both anti-inflammatory and analgesic properties, and may therefore be useful in filling an unmet need, in the treatment of rheumatoid and other forms of arthritis, especially in the light of its analgesic properties.

KEY WORDS: Rheumatoid Arthritis, T cells, B cells, Rodent

{dagger}The last two authors contributed equally as senior authors.

Submitted 21 March 2007; revised version accepted 18 May 2007.
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