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Rheumatology Advance Access originally published online on September 27, 2008
Rheumatology 2008 47(11):1727-1728; doi:10.1093/rheumatology/ken372
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© The Author 2008. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

LETTERS TO THE EDITOR

High circulating levels of VEGF-C suggest abnormal lymphangiogenesis in systemic sclerosis

S. Chitale1, A. F. Al-Mowallad2, Q. Wang2, S. Kumar2 and A. Herrick1

1University of Manchester, Salford Royal NHS Foundation Trust, Salford and 2Department of Pathology, Stopford building, Medical School, Manchester University, Manchester, UK

Correspondence to: S. Chitale, Department of Rheumatology, University Hospital Aintree, Liverpool L9 7AL, UK. E-mail: sarangchitale@hotmail.com

The first 10% of the full text of this article appears below.

SIR, SSc is a multisystem autoimmune disorder characterized by distinctive vascular abnormalities, immune dysfunction and fibrosis of skin and internal organs. The two major subtypes, limited cutaneous SSc (LSSc) and diffuse cutaneous SSc (DSSc), are defined on the basis of the extent of the cutaneous involvement and have different natural histories, patterns of internal organ involvement and prognoses [1]: as a generalization, vascular abnormalities are more pronounced in . . . [Full Text of this Article]


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