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Rheumatology Advance Access originally published online on January 28, 2008
Rheumatology 2008 47(3):379-380; doi:10.1093/rheumatology/kem347
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© The Author 2008. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Autologous skin grafting—a limb-saving procedure in a patient with diffuse cutaneous systemic sclerosis

S. Chitale1, J. Watson2 and A. Herrick1

1Rheumatic Diseases Centre, University of Manchester, Hope Hospital, Salford and 2South Manchester University Hospitals, Wythenshawe Hospital-Plastic Surgery, Wythenshawe, Manchester, UK

Correspondence to: S. Chitale, Rheumatic Diseases Centre, Hope Hospital, Stott Lane, Salford. M6 8HD, UK. E-mail: sarangchitale@hotmail.com

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SIR, Systemic sclerosis (SSc) is a connective tissue disorder characterized by interplay between early immunological events and vascular changes, resulting in the generation of a population of activated fibroblasts, generally considered to be the effector cell in the disease [1]. These fibroblasts are responsible for overproduction of collagen, leading to the thickening and tightening of the skin. This skin tightening, together with the characteristic microvascular changes of SSc, can compromise wound healing. For . . . [Full Text of this Article]


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