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Rheumatology Advance Access originally published online on March 27, 2008
Rheumatology 2008 47(5):738-739; doi:10.1093/rheumatology/ken113
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© The Author 2008. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Rituximab in rheumatoid arthritis following anti-TNF-associated tuberculosis

M. L. Burr1, A. P. Malaviya1, J. H. Gaston1, A. J. Carmichael2 and A. J. K. Östör1

1Department of Rheumatology and 2Department of Infectious Diseases, Addenbrooke's Hospital, Cambridge, UK.

Correspondence to: M. L. Burr, Rheumatology Research Unit, Addenbrooke's Hospital, Box 194 E6, Hills Road, Cambridge CB2 2QQ, UK. E-mail: marianlburr@doctors.org.uk

The first 10% of the full text of this article appears below.

SIR, The link between anti-TNF therapy and reactivation of latent tuberculosis (TB) is well recognized [1–3]. These patients are more likely to present with disseminated infection and this carries considerable mortality. Managing active RA in patients with anti-TNF-associated TB can therefore be challenging. We present the case of a patient with RA who was successfully treated with rituximab, a chimaeric anti-CD20 monoclonal antibody, after developing disseminated isoniazid-resistant TB following treatment with infliximab.

A 54-yr-old white female with a 15-yr history of severe . . . [Full Text of this Article]


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