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Rheumatology Advance Access originally published online on January 31, 2008
Rheumatology 2008 47(6):771-776; doi:10.1093/rheumatology/kem352
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© The Author 2008. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

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Signalling, inflammation and arthritis

Crossed signals: the role of interleukin (IL)-12, -17, -23 and -27 in autoimmunity

V. Paunovic, H. P. Carroll, K. Vandenbroeck and M. Gadina

Centre for Cancer Research and Cell Biology. Queen's University Belfast, UK.

Correspondence to: M. Gadina, Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, BT9 7BL, Northern Ireland, UK. E-mail: m.g.gadina{at}qub.ac.uk


  Abstract

Autoimmune diseases such as rheumatoid arthritis are the consequence of a persistent imbalance between pro- and anti-inflammatory immune mechanisms leading to chronic inflammation. The action of several cytokines is at the basis of this complex process. This review is focused on the signalling events triggered by two major groups of cytokines, namely the IL-12 and IL-17 families, which in the past few years have been shown to have a prominent role in the pathogenesis of such diseases. In particular, we will focus on the signalling cascades set in motion by such cytokines and how this may relate to the pathogenesis of human immune and inflammatory disorders as knowledge of such cascades may help in the development of novel therapeutic approaches for such diseases.

KEY WORDS: Inflammation, Autoimmunity, Rheumatoid arthritis, Cytokines, Interleukins, Interferons, T helper, Signal transduction, Jak–STAT pathway, Animal models

Submitted 18 May 2007; revised version accepted 30 November 2007.
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H. P. Carroll, V. Paunovic, and M. Gadina
Signalling, inflammation and arthritis: Crossed signals: the role of interleukin-15 and -18 in autoimmunity
Rheumatology, September 1, 2008; 47(9): 1269 - 1277.
[Abstract] [Full Text] [PDF]


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