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Rheumatology Advance Access originally published online on October 17, 2008
Rheumatology 2009 48(3):210-212; doi:10.1093/rheumatology/ken394
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© The Author 2008. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

EDITORIALS

Vitamin D and autoimmune rheumatic diseases

M. Cutolo1

1Research Laboratories and Clinical Academic Unit of Rheumatology, University of Genova, Genova, Italy

Correspondence to: M. Cutolo, Research Laboratories and Clinical Academic Unit of Rheumatology, University of Genova, Viale Benedetto XV, 6, 16132 Genova, Italy. E-mail: mcutolo@unige.it

The first 150 words of the full text of this article appear below.

Introduction

Vitamin D is classified as a secosteroid in which one of the rings has been broken, in this case by ultraviolet B sunlight, and the main source of vitamin D is de novo synthesis in the skin. Although vitamin D is consumed in food, dietary intake alone is often insufficient, supplying only 20% of the body's requirements.

In recent years, the discovery of the vitamin D receptor (VDR) in the cells of the immune system and the fact that several of these cells produce the vitamin D hormone suggested that it could have immunoregulatory properties.

However, vitamin D insufficiency is emerging as a clinical problem of global proportions and epidemiology has linked vitamin D status with autoimmune disease susceptibility and severity [1].

Therefore, 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] the biologically active metabolite of Vitamin D3, not only regulates bone and calcium metabolism but also exerts . . . [Full Text of this Article]

The mechanisms of vitamin D immunomodulation

Vitamin D and autoimmune rheumatic diseases

RA

SLE

Conclusions


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[Abstract] [Full Text] [PDF]