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Rheumatology Advance Access originally published online on March 25, 2009
Rheumatology 2009 48(6):618-621; doi:10.1093/rheumatology/kep053
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© The Author 2009. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

6q23 polymorphisms in rheumatoid arthritis Spanish patients

Nieves Perdigones1, José Ramón Lamas2, Ana G. Vigo1, Emilio G. de la Concha1, Juan Angel Jover2, Elena Urcelay1, Benjamín-Fernández Gutiérrez2 and Alfonso Martínez1

1Immunology Department and 2Rheumatology Department, Hospital Clínico San Carlos, Madrid, Spain.

Correspondence to: Alfonso Martínez Doncel, Immunology Department, Hospital Clínico San Carlos, C/Profesor Martín Lagos, s/n. 28040 Madrid, Spain. E-mail: alfmdoncel{at}gmail.com


  Abstract

Objective. The aim of this work is to replicate the role of two recently described RA genetic markers (rs10499194 and rs6920220) situated at 6q23 in the autoantibody-positive phenotype.

Methods. A case–control study (630 RA patients and 664 healthy blood donors, all white Spaniards) was performed with two single nucleotide polymorphisms (rs6920220 and rs10499194) situated at 6q23. Genotyping was performed by TaqMan technology; autoantibody-stratified analyses in RA patients were also undertaken to replicate the previously reported effect of these polymorphisms.

Results. No association was observed for rs10499194 even after autoantibody stratification. The minor allele frequency of rs6920220 was higher in anti-CCP or RF-positive patients than in controls (P = 0.014 and P = 0.015 respectively), thus replicating previous findings.

Conclusions. Our data replicate the association of rs6920220 with autoantibody-positive RA disease, although not for rs10499194.

KEY WORDS: Single nucleotide polymorphism, Rheumatoid arthritis, Genetics, Susceptibility, Anti-cyclic citrullinated peptide antibody, 6q23

Submitted 30 September 2008; revised version accepted 12 February 2009.
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