Rheumatology Advance Access published online on February 28, 2003
Rheumatology, doi:10.1093/rheumatology/keg163
Rheumatology © British Society for Rheumatology 2003; all rights reserved
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Original Papers
1 Division of Rheumatology, Department of Internal Medicine, University Hospital, Geneva, Switzerland
* Corresponding author. E-mail: sylvette.bas{at}hcuge.ch.
Received 11 July 2002
; accepted 9 October 2002
Objectives. To compare the synovial fluid (SF) concentrations of various cytokines in rheumatoid arthritis (RA) and in reactive arthritis, and to look for a correlation between cytokine levels and the presence of HLA-B27 antigen in reactive arthritis patients. Methods. Concentrations of interleukin (IL) 10, IL-12, IL-18, interferon Results. The SF concentrations of IL-10 were significantly lower in patients with reactive arthritis (median 2.3 pg/ml) than in RA patients (median 14.6 pg/ml). The SF levels of IFN- Conclusions. The lower IFN-
Key words: Cytokines, Synovial fluid, Reactive arthritis, Chlamydia trachomatis, Interferon Lower level of synovial fluid interferon-
in HLA-B27-positive than in HLA-B27-negative patients with Chlamydia trachomatis reactive arthritis
2 Oslo City Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway
(IFN-) and tumour necrosis factor 
(TNF-) were determined by commercially available enzyme-linked immunosorbent assays (ELISA) in the SF from 48 patients with reactive arthritis, 33 with RA and 13 with osteoarthritis (non-inflammatory controls). were not significantly different but the ratios of IFN- to IL-10 were significantly higher in patients with reactive arthritis (median 9.2) than in RA patients (median 0.83). When the subset of patients with Chlamydia trachomatis reactive arthritis was considered, the SF concentration of IFN- was significantly lower in HLA-B27-positive (median 2.9 pg/ml) than in HLA-B27-negative patients (median 42.4 pg/ml). After 2 yr of follow-up, two HLA-B27-positive patients, who had low SF levels of IFN-, had a chronic course of arthritis, whereas after 1 yr all HLA-B27-negative patients had complete resolution of arthritis. concentrations in HLA-B27-positive patients with C. trachomatis reactive arthritis could be related to the tendency of these patients to have more severe or chronic arthritis..
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