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Rheumatology Advance Access published online on February 28, 2003
Rheumatology, doi:10.1093/rheumatology/keg168
Rheumatology © British Society for Rheumatology 2003; all rights reserved
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© 2003 British Society for Rheumatology 2003; all rights reserved

Original Papers

Elevated levels of synovial fluid antibodies reactive with the small proteoglycans biglycan and decorin in patients with rheumatoid arthritis or other joint diseases

A. Polgár 1, A. Falus 2, É. Koó 3, I. Ujfalussy 3, M. Seszták 1, I. Szuts 1, K. Konrád 1, L. Hodinka 1, É. Bene 3, Gy. Mészáros 3, Zs. Ortutay 2, É. Farkas 2, A. Paksy 4, E. I. Buzás 2*

1 National Institute of Rheumatology and Physiotherapy, Budapest
2 Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest
3 National Institute of Rheumatology and Physiotherapy, Budapest; Polyclinic of Hospitaller Brothers of St John of God in Budapest
4 Biometry Unit, Semmelweis University, Budapest, Hungary

* Corresponding author. E-mail: buzedi{at}dgci.sote.hu.

Received 5 December 2001 ; accepted 18 October 2002

Abstract

Objectives. To determine whether patients with rheumatoid arthritis (RA) express humoral immunity to the small proteoglycans biglycan and decorin and to compare the response to that of patients suffering from other joint diseases.

Methods. Serum and synovial fluid IgG and IgM antibody levels were determined by enzyme-linked immunosorbent assay. Antibodies to biglycan and decorin as well as to other known and extensively investigated cartilage matrix components such as type II collagen, aggrecan and fibronectin were investigated. Patients suffering from RA, osteoarthritis (OA), psoriatic arthritis and other seronegative spondylarthropathies were included in the study. Correlation between antibody levels and clinical/laboratory parameters was determined.

Results. Patients with RA expressed an increased humoral immunity to biglycan, while patients with seronegative spondylarthropathies displayed elevated decorin-specific synovial antibody levels compared with OA patients.

Conclusion. These results indicate a significantly higher immunity to small proteoglycans in RA and seronegative spondylarthropathies than in OA suggesting a possible involvement in the pathogenesis of inflammatory rheumatic diseases.

Key words: Biglycan, Decorin, Aggrecan, Collagen, Fibronectin, Antibody, RA
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