Skip Navigation



Rheumatology Advance Access published online on April 16, 2003
Rheumatology, doi:10.1093/rheumatology/keg232R
Rheumatology © British Society for Rheumatology 2003; all rights reserved
This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
42/7/860    most recent
keg232v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Karasneh, J.
Right arrow Articles by Gul, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Karasneh, J.
Right arrow Articles by Gul, A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 2003 British Society for Rheumatology

Original Papers

Association of specific interleukin 1 gene cluster polymorphisms with increased susceptibility for Behçet's disease

J. Karasneh 1, A. H. Hajeer 1, J. Barrett 2, W. E. R. Ollier 1*, M. Thornhill 3, A. Gul 4

1 ARC Epidemiology Unit, University of Manchester, Manchester
2 ICRF Genetic Epidemiology Laboratory, St James's University Hospital, Leeds
3 Oral Disease Research Centre, Bart's and the London, Queen Mary's School of Medicine and Dentistry, UK
4 Division of Rheumatology, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey

* Corresponding author. E-mail: bill{at}fs1.ser.man.ac.uk.

Received 22 July 2002 ; accepted 3 December 2002

Abstract

Objective. The aim of this study was to investigate if the inheritance of specific polymorphisms of interleukin 1 (IL-1) A, IL-1B and IL-1 receptor antagonist (IL-1RN) genes could affect the susceptibility to Behçet's disease (BD).

Methods. A total of 132 BD patients and 105 healthy controls were genotyped for IL-1A -889, IL-1B -511, -35, +5810, +5887, and IL-1RN +8006, +8061, +9589, +11100 single nucleotide polymorphisms, and IL-1RN 86-bp variable number of tandem repeat polymorphism. {chi}2-analysis was used to compare the allele and genotype frequencies of the cases and controls. IL-1A and IL-1B haplotypes were reconstructed using the Phase program.

Results. Inheritance of the C allele of the IL-1A -889 polymorphism was associated with BD (OR=2.0, P=0.01) and inheritance of the IL-1A -889C/IL-1B +5887T haplotype was identified as an increased risk for BD. The IL-1A -889 and IL-1B +5887 CC/TT combined genotype was significantly more observed in BD cases than in controls (57.5 vs 38.1%, OR=2.2, P=0.003). No association with BD was found for other investigated polymorphisms in the IL-1B and IL-1RN genes.

Conclusion. Susceptibility to BD is increased in individuals carrying both the IL-1A -889C and IL-1B +5887T haplotype. Individuals who are both homozygous CC at IL-1A -889 and TT at IL-1B +5887 appear to have twice the risk of developing BD as individuals having other IL-1A -889/IL-1B +5887 genotypes.

Key words: Behçet's disease, Interleukin 1, IL-1 receptor antagonist, Single nucleotide polymorphism, Haplotype.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Immunol.Home page
M. J. Mattapallil, A. Sahin, P. B. Silver, S.-H. Sun, C.-C. Chan, E. F. Remmers, J. F. Hejtmancik, and R. R. Caspi
Common Genetic Determinants of Uveitis Shared with Other Autoimmune Disorders
J. Immunol., May 15, 2008; 180(10): 6751 - 6759.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.